Danny Robinson’s side travel to the Webbswood Stadium bursting with confidence after a 6-0 thrashing of AFC Totton last week.
Swindon, meanwhile, approach the game with renewed fitness after their fixture with Hayes and Yeading was postponed.
The Marine sit eighth in the Southern League Premier Division South and will be playing their first FA Trophy fixture of the season.
Thatcham, however, featured in the Preliminary stage and overcame Barnstaple in a convincing 3-1 win two weeks ago with Callum Willmoth bagging a brace.
A win for the Kingfishers would extend an incredible unbeaten run to eight games in all competitions.